This method enables linking transcriptional variability to epigenetic heterogeneity. Tumor-cell trajectories in organoid and mouse models Go to Website Navigation: Home; about narcis; login; Nederlands; contact. Partnership Agreement for Pontiac School District - Free download as PDF File (.pdf) or read online for free. Read the new partnership agreement between Pontiac School District and the state including exhibits of data on the schools achievement gaps. Save the date for our Annual Conference! Jop Kind, Junior Group Leader at the Hubrecht Institute. Former EMBL Genome Biology PhD student, Jop Kind, has been selected as this year’s John Kendrew Young Scientist Award winner for pioneering postdoctoral work in establishing novel technologies to map chromatin domains in single cells. Scientists from the groups of Puck Knipscheer (Hubrecht Institute) and Ketan J. Patel (MRC Laboratory of Molecular Biology) studied the second line of … Institute of Molecular Biotechnology, Austrian academy of science. 13:35. Anna Kicheva IST Austria Verified email at ist.ac.at. Royal Netherlands Academy of Arts & Sciences (KNAW) Phone +31 (0)30 212 1800; Email communication@hubrecht.eu; Website http://www.hubrecht.eu/ Electronic address: j.kind@hubrecht.eu. (Jop) Kind: Active at: The Netherlands Cancer Institute: Hubrecht Institute for Developmental Biology and Stem Cell Research: Email address: If you have any questions or problems regarding login, please contact narcis@dans.knaw.nl. Despite extensive research into the molecular pathways that sense and repair DNA double-strand breaks (DSBs), comparatively little is known about management of breaks within different genomic and chromatin contexts. Jop Kind Group Leader at Hubrecht Institute, Developmental Biology and Stem Cell Research Amsterdam en omgeving, Nederland Meer dan 500 connecties Nederland, © Copyright 2021 Privacypolicy Hubrecht Institute, A major interest in the group is how gene-expression control is achieved in early embryogenesis. Jop is currently an associate professor at the Hubrecht Institute in Utrecht where his lab continues to develop new techniques to single-cell profile gene-regulation to obtain better insights into the mechanisms that govern cell fate choice in development and disease. He will zoom in on single-cell epigenomics and multi-omics. In this conversation. Accurate repair of DNA damage is critical for the maintenance of genomic integrity. Jop Kind lab. Contact. Kim L de Luca 1 , Jop Kind 2 ... 1 Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), University Medical Center Utrecht and Oncode Institute, Utrecht, The Netherlands. Seeing is sequencing: linking phenotypes and genotypes of heterogeneous cancer cells by high-throughput, microscopy-based single cell selection and functionally annotated single cell sequencing. We use this approach to understand how gene-expression is controlled and to obtain insight into the regulatory mechanisms that govern cellular decision making in mouse early embryogenesis. Isabel Guerreiro 1 , Jop Kind 2 Affiliations 1 Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands. Jop Kind EMBL: Predoc, Akhtar group, Genome Biology, 2002-2008. The aim of the lab is to understand the principles governing cellular decision-making. j.kind@hubrecht.eu. 7 Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands. 12:35. Single cell epigenomics. ERC-starting grant for Marvin Tanenbaum and Jop Kind Marvin Tanenbaum and Jop Kind, both group leader at the Hubrecht Institute, are awarded an ERC-starting grant. “Our overarching goal is to further research current pathways and discover new ones in order to better understand how cells repair this type of DNA damage”, says Knipscheer. About. Puck Knipscheer Group. Jop Kind. Over 17 years of experience in Molecular Biology, Yuva completed her MSc. Over 17 years of experience in Molecular Biology, Yuva completed her MSc. 2 Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), University Medical Center Utrecht and Oncode Institute, Utrecht, The Netherlands. PhD. Molecular biologist dr. Jop Kind (1978) joined the Van Steensel lab as a postdoc after a highly successful PhD at the EMBL. Miao-Ping Chien. Kim L de Luca 1 , Jop Kind 2 Affiliations 1 Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), University Medical Center Utrecht and Oncode Institute, Utrecht, The Netherlands. Ester Frische; Mariëlle Harlé; Yuva Oz; Jacqueline Staring; Peter Thijssen; More information will follow. Jop Kind leads a Developmental Epigenomics group at Hubrecht Institute, Netherlands. To be announced. Their combined citations are counted only for the first article. 3,331. PMID: 31118510 PMCID: PMC6546605 This is harmful because it prevents the DNA from replicating and thereby makes it impossible for cells to divide. That knowledge underlines the link between alcohol consumption and cancer. Online event. Despite extensive research into the molecular pathways that sense and repair DNA double-strand breaks (DSBs), comparatively little is known about management of breaks within different genomic and chromatin contexts. Annual Scientific Meeting. Royal Netherlands Academy of Arts & Sciences (KNAW), Hubrecht Institute; 2015 2020. The grant was awarded to only 327 out of 2506 applicants. The grant enables them to develop their own innovative line of research and set up their own research group. Wednesday 22 July. Articles … Susanne Lens Group. By Jop Kind, Hubrecht Institute. Electronic address: j.kind@hubrecht.eu. Chromatin cartographer EMBL alumnus Jop Kind, this year’s John Kendrew Award winner, reflects on the imaginative questions that led him to the prize . Additionally, they are planning to build so-called molecular time machines: by giving cells a mark in the earliest stages of embryonic development, the researchers can – once the cell has made its choice – trace the epigenetic status of the cells during the earlier stages of development. https://lnkd.in/ekB-EJy #outsmartingcancer Hubrecht Institute, Developmental Biology and Stem Cell Research Knipscheer and Kind receive prestigious ERC Consolidator grant hubrecht.eu Geert Kops Group. Cited by. Save the date! PMID: 32350457 DOI: 10.1038/s41596-020-0314-8 3584 CT Utrecht torres-padilla@helmholtz-muenchen.de. Contact Information Mariëlle Harlé Other Events. To study DSB-repair in single cells, we have adapted scDam&T to generate maps of DSB-repair sites in single cells. Jop Kind is group leader at the Hubrecht Institute and Oncode investigator. Oncode is an independent institute dedicated to understanding cancer and translating research into practice. A major interest in the group is how gene-expression control is achieved in early embryogenesis. A large proportion of the metazoan genome is spatially segregated at the nuclear periphery through genomic contacts with the nuclear lamina, a thin meshwork of lamin filaments that lines the inner-nuclear membrane. PHOTO: EMBL . In addition, we profile the epigenetic landscapes, chromatin accessibility and transcriptome in single cells. 2 day event 19 - 20 Apr. The researchers are each given two million euros to strengthen their research groups and continue their innovative research in the next 5 years. Kind’s work has paved the way for the development of powerful technologies to map chromatin, or balled-up DNA, in single cells, earning him this year’s John Kendrew Award. 2016: Group Leader, Hubrecht Institute, Utrecht, The Netherlands. The Consolidator Grant is specifically awarded to researchers who have formed their own research group relatively recently and aim to further strengthen it further. Wouter de Laat Group. Jobs. Jop Kind is group leader at the Hubrecht Institute and Oncode Investigator. 3,331. Jop Kind EMBL: Predoc, Akhtar group, Genome Biology, 2002-2008. * Correspondence: j.kind@hubrecht.eu † These authors contributed equally to this work. Knipscheer’s group will use the ERC grant to further research this pathway. Friends raise €290.800,- for Hubrecht Institute. More information. Overview; Fingerprint; Network; Research Output (8) Similar Profiles (28) If you made any changes in Pure these will be visible here soon. 13:05. We employ our single-cell genomic methods to study cellular trajectories on route towards malignant metastatic identities. Former EMBL Genome Biology PhD student, Jop Kind, has been selected as this year’s John Kendrew Young Scientist Award winner for pioneering postdoctoral work in establishing novel technologies to … Chromosomal regions that associate with a thin filamentous lamina layer at the nuclear periphery are generally in an inactive transcriptional state (Guerreiro and Kind, 2019, Curr.Opin.Gen.Dev.). Research output per year. Since October 2014 he is Junior Group Leader at the Hubrecht Institute. Title. He made visible how 6 feet of DNA is dispersed in a cell nucleus of 10 micrometres. Nederland, © Copyright 2021 Privacypolicy Hubrecht Institute. The institute encompasses 23 research groups that perform fundamental, multidisciplinary research on healthy and diseased cells, tissues and organisms. We use this approach to understand how gene-expression is controlled and to obtain insight into the regulatory mechanisms that govern cellular decision making in mouse early embryogenesis. Save the date! The nuclear lamina (NL) is a thin meshwork of filaments that lines the inner nuclear membrane, thereby providing a platform for chromatin binding and supporting genome organization. hubrecht.eu. Network. Because DamID-signals are stable and can be carried-over for multiple generations, we are also looking into ways to exploit this property of DamID to study DSB-repair in the context of cellular decision making. 23. … ERC-starting grant for Marvin Tanenbaum and Jop Kind. We profiled these genome-lamina interactions in single cells to obtain better understanding in gene-regulation control in pre- and post-implantation embryos (Borsos et al., 2019, Nature) (. Additionally, they study how new cell types arise in the early development of mouse embryos, in which epigenetics plays an important role. Molecular mechanisms and regulation of DNA repair; Hubrecht Institute. Reads . Read more | 5 November . Merged citations. That way, we hope to better understand the relationship between epigenetics and the emergence of new cell types”, says Kind. EMBL alumnus Jop Kind’s research focuses on the role of DNA organisation in genome stability, cell development and disease. Miao-Ping Chien. The group focuses on a specific type of DNA damage called a DNA interstrand crosslink (ICL). Jobs; Jobs Tips; 11 Recession-Proof Jobs; How to Get a Job; The Perfect Resume Looks Like This; How to Write A Cover Letter; 9 Attention-Grabbing Cover Letter Examples; New On Glassdoor; Best Cities for Jobs 2020; Company Reviews . KIT, Royal Tropical Institute. Sort. Job Corps is the largest Free residential education and job training program for young adults ages 16–24.. We connect you with the skills and education you need to get the career you want! Further, in the same cells, we also profile genome-wide chromatin states with a chromatin immunocleavage (ChIC) approach to study the relationships between DSB-repair and the local chromatin environment (. ‪Hubrecht Institute‬ - ‪Cited by 3,964‬ - ‪Single cell epigenomics‬ Citations per year. Hubrecht Institute Summary: ... but instead attached to the ceiling at anchor points," says Jop Kind, group leader at the Hubrecht Institute. Hubrecht Institute launches new website! Verified account Protected Tweets @; Suggested users Jop Kind, group leader at the Hubrecht Institute, has been awarded the John Kendrew award. j.kind@hubrecht.eu. As a postdoctoral fellow in the lab of Bas van Steensel at the NKI, Jop developed novel techniques to visualize and profile single-cell spatial genome organization. 2 Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands. To study DSB-repair in single cells, we have adapted scDam&T to generate maps of DSB-repair sites in single cells. 13:05. The researchers are each given two million euros to strengthen their research groups and continue their innovative research in the next 5 years. Publications. Maria-Elena Torres-Padilla is group leader and director of the Institute of Epigenetics and Stem Cells (IES), Helmholtz Center Munich and professor of Stem cell biology at the Ludwig-Maximilians University. About the Hubrecht Institute To this end we employ and continuously develop novel single-cell technologies to delineate these processes with high sensitivity and accuracy. Oncode, starting from a deeper understanding of the basics of cancer, works to come up with better treatments and improved diagnostics. Hubrecht Institute opens new laboratory building. We are employing scDam&T to obtain a better understanding of the epigenetic mechanisms underlying lineage decisions in early embryogenesis, to identify the epigenetic trajectories of single cells that acquire malignant identities in tumorigenesis and to obtain insight into the role of chromatin in DNA double-strand repair. Biomedical genomics; 13:05. These topic labels come from the works of this person. Additionally, they will investigate whether there are other, currently unknown pathways involved in repairing ICLs. An ICL occurs when the two strands of our DNA are connected unnaturally. The Kind group uses a combination of single-cell genomics and microscopy methods to study the role of chromatin and epigenetics in gene-regulation control, with a focus on early mouse embryonic development and tumorigenesis. Uppsalalaan 8 We have developed scDam&T, a method to simultaneously capture protein-DNA interactions and transcriptomes in the same cell (Rooijers et al, 2019, Nature Biotechnology) (Figure 1). Annual Scientific Meeting. This type of DNA damage can have an endogenous cause, but it can also be caused by external influences, such as high dosages of chemotherapy in cancer. Erasmus University Medical Center/ UFO Biosciences, NL . Further, in the same cells, we also profile genome-wide chromatin states with a chromatin immunocleavage (ChIC) approach to study the relationships between DSB-repair and the local chromatin environment (Figure 3). j.kind@hubrecht.eu. A. Lochs †, Samy Kefalopoulou † and Jop Kind * Oncode Institute, Hubrecht Institute–KNAW and University Medical Center Utrecht, 3584 Utrecht, The Netherlands; s.lochs@hubrecht.eu (S.J.A.L. The ERC-starting grants are awarded to support up-and-coming research leaders who have recently established their own research team in Europe. Hubrecht Institute, NL. Cell-fate decisions and the role of epigenetics in DNA double-strand repair Genome instability; UMC Utrecht. jop kind Hubrecht Institute Verified email at hubrecht.eu. Genomic regions contacting the NL are lamina associated domains (LADs), which contain thousands of genes that are lowl … Hubrecht Institute, Developmental Biology and Stem Cell Research | 6,134 followers on LinkedIn. This "Cited by" count includes citations to the following articles in Scholar. Verified email at hubrecht.eu. Follow. ); s.kefalopoulou@hubrecht.eu (S.K.) Modifications of the conceptus exposed key genes regulating these tissues co-development. Hubrecht Institute. Jop Kind, Group Leader at Hubrecht Institute and Oncode Investigator, will bring you up to speed with the basics of Single Cell Technology. A. Lochs †, Samy Kefalopoulou † and Jop Kind * Oncode Institute, Hubrecht Institute–KNAW and University Medical Center Utrecht, 3584 Utrecht, Publications 23. Dive into the research topics where Jop Kind is active. Oncode unites science, collaboration and valorization to create impact for patients. Jop Kind lab. Jop Kind, group leader at the Hubrecht Institute, has been awarded a NWO Vidi-grant. Mechanisms underlying cell-fate choice in early embryogenesis A major interest in the group is how gene-expression control is achieved in early embryogenesis. She and others previously discovered that the Fanconi anemia (FA) pathway plays a crucial role in repairing ICLs. EMBL alumnus Jop Kind’s research focuses on the role of DNA organisation in genome stability, cell development and disease. Silke J. Articles Cited by. Salaries, reviews and more - all posted by employees working at Hubrecht Institute. 2 day event 04 - 05 Nov. Oncode - CGC Annual Conference: Basic biology meets Cancer research. Jop Kind Group. This is particularly difficult to study because DSBs occur randomly in the genome, thus every single cell harbors a different DSB-landscape. jop kind. The European Research Council (ERC) awards grants to individual scientists of all nationalities and ages who perform groundbreaking research. Here For You During COVID-19 NEW! Molecular biologist dr. Jop Kind (1978) joined the Van Steensel lab as a postdoc after a highly successful PhD at the EMBL. Jobs. Because DamID-signals are stable and can be carried-over for multiple generations, we are also looking into ways to exploit this property of DamID to study DSB-repair in the context of cellular decision making. To achieve this, we make use of organoid and mouse models that capture tumorigenesis all the way from the initiating stages towards metastasis. Jop Kind, Junior Group Leader at the Hubrecht Institute. ). The early mammalian conceptus (blastocyst) contains two supporting extraembryonic tissues - the trophectoderm and the primitive endoderm (PrE) - that encase and guide the epiblast (Epi) to eventually form the all body. Fingerprint. 12:35. We profiled these genome-lamina interactions in single cells to obtain better understanding in gene-regulation control in pre- and post-implantation embryos (Borsos et al., 2019, Nature) (Figure 2). Technology development Puck Knipscheer and Jop Kind, both group leader at the Hubrecht Institute and Oncode investigator, individually receive a prestigious European Research Council (ERC) Consolidator Grant. Award ceremony photo gallery. Hubrecht Institute. 7 Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands. Puck Knipscheer is group leader at the Hubrecht Institute and Oncode investigator. Biomedical genomics; Hubrecht Institute. Online event. Afterwards, Alexander van Oudenaarden, Mauro Muraro and Waleed Kholosy will also give talks and elaborate on some specific applications and usage of single cell technology. Other Annotations. Former EMBL Genome Biology PhD student, Jop Kind, has been selected as this year’s John Kendrew Young Scientist Award winner for pioneering postdoctoral work in establishing novel technologies to map chromatin domains in single cells. See what employees say about what it's like to work at Hubrecht Institute. Read more | 11 November . The John Kendrew Young Scientist Award (JKA) was launched in 2007 as an initiative from the EMBL Pensioner’s Association to honour EMBL’s first Director General, Sir John Kendrew (1975-1982), and to support scientists in the early stages of their career. That knowledge underlines the link between alcohol consumption and cancer. 3 Institute of Epigenetics and Stem Cells (IES), Helmholtz Zentrum München, Munich, Germany. Best Cities for Jobs 2020 NEW! hubrecht.eu. Jop Kind. Mechanisms underlying cell-fate choice in early embryogenesis KIT, Royal Tropical Institute. An important contributor to the regulation of gene expression is the spatial positioning of genes within the 3-dimensional space of the nucleus. Jop Kind Group Jop Kind Oncode Investigator at Hubrecht Institute My Research. By Jop Kind, Hubrecht Institute. About. Past events. Network. Visit Kind's page. Year; Systematic protein location mapping reveals five principal chromatin types in Drosophila cells. Accurate repair of DNA damage is critical for the maintenance of genomic integrity. The Hubrecht Institute is a research institute of the Royal Netherlands Academy of Arts and Sciences (KNAW), situated on the Utrecht Science Park. Since October 2014 he is Junior Group Leader at the Hubrecht Institute. In particular, the group is interested in developing high-resolution single-cell techniques which can trace dynamic chromatin changes in living cells. Jop Kind Group. We are particularly interested in understanding the role of epigenetics and spatial genome organization in this process. Cell division & chromosome segregation; Hubrecht Institute. Chromosomal regions that associate with a thin filamentous lamina layer at the nuclear periphery are generally in an inactive transcriptional state (Guerreiro and Kind, 2019, Curr.Opin.Gen.Dev.). Recently, however, her group also discovered a new pathway that is involved in ICL repair; they aim to further study this newly found DNA repair route. Furthermore, as we consider technology development a core business of the group, we are continuously exploring ways to obtain richer single-cell datasets. Publications. Verified email at imba.oeaw.ac.at - Homepage. Jop Kind. Publications 23. His group is focused on understanding how spatial and temporal changes in genome architecture affect gene expression. Chromatin cartographer EMBL alumnus Jop Kind, this year’s John Kendrew Award winner, reflects on … Protein–DNA interactions are essential for establishing cell type–specific chromatin architecture and gene expression. 2016: Group Leader, Hubrecht Institute, Utrecht, The Netherlands. Researchers of the Hubrecht Institute (KNAW) in Utrecht, The Netherlands, and the MRC Laboratory of Molecular Biology in Cambridge, United Kingdom, have discovered a new way in which the human body repairs DNA damage caused by a degradation product of alcohol. Spatiotemporal regulation of genomic function; Hubrecht Institute. Seeing is sequencing: linking phenotypes and genotypes of heterogeneous cancer cells by high-throughput, microscopy-based single cell selection and functionally annotated single cell sequencing. Hubrecht Institute, NL. Jop Kind, Junior Group Leader at the Hubrecht Institute. Jop, now Group Leader at … Read more | 18 November . The researchers in Kind’s group will use the ERC grant to further research when and how cells make these identity choices. j.kind@hubrecht.eu. Jop, now Group Leader at … Puck Knipscheer Group. Reads . An important contributor to the regulation of gene expression is the spatial positioning of genes within the 3-dimensional space of the nucleus. We are interested in how cells acquire new identities and traits in lineage specification events in mice and in cancer. Uppsalalaan 8 The Kind group researches gene regulation – how genes are turned on or off – and the influence of the packing of DNA, the epigenetics, on this mechanism. Contact. Salaries, reviews, and more - all posted by employees working at Hubrecht Institute. Together with her group, Knipscheer studies the repair pathways that cells use to correct ICLs. Sara is now working as a computational biologist in the lab of Jop Kind at the Hubrecht Institute (Netherlands). Hubrecht Institute. This is particularly difficult to study because DSBs occur randomly in the genome, thus every single cell harbors a different DSB-landscape. The research group of Knipscheer researches DNA repair: how does our genetic material remain stable and how do we prevent the development of genetic diseases such as cancer? The grant allows her to expand her group with 4 researchers for the duration of 5 years. 2016: Group Leader, Hubrecht Institute, Utrecht, The Netherlands. Jop Kind The organization of DNA within the eukaryotic nucleus is important for cellular processes such as regulation of gene expression and repair of DNA damage. Oncode Investigator at Hubrecht Institute My Research Jop Kind received his PhD from the Radboud University Nijmegen in 2008 for his work on chromatin and gene expression in the research group of Asifa Akhtar at EMBL Heidelberg. Cell division & chromosome segregation; Hubrecht Institute. He made visible how 6 feet of DNA is dispersed in a cell nucleus of 10 micrometres. Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands. About. 3584 CT Utrecht 23. Sort by citations Sort by year Sort by title. Projects 1. Bob Roberts 2020-04-16 23:48:49? Wouter de Laat Group. 7 Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands. ). Projects 1. Cited by. Royal Netherlands Academy of Arts & Sciences (KNAW) Phone +31 (0)30 212 1800; Email communication@hubrecht.eu; Website http://www.hubrecht.eu/ Jop Kind received his PhD from the Radboud University Nijmegen in 2008 for his work on chromatin and gene expression in the research group of Asifa Akhtar at EMBL Heidelberg. 2 day event 04 - 05 Nov. Oncode - CGC Annual Conference: Basic biology meets Cancer research . In addition, scDam&T allows determining cellular identity of cells in complex tissues -such as embryos or tumors- based on transcriptomics, in direct relation to their epigenetic regulatory landscapes (DamID). To obtain detailed insight into this trajectory, it is essential to capture all the stages with single-cell accuracy. Jop Kind. 2 Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands. martin 1st April 2015 News Read more Hiding in plain sight 2 Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands. Biography. Duplicate citations. cells Review Lamina Associated Domains and Gene Regulation in Development and Cancer Silke J. Save the date for our Annual Conference! Jop Kind obtained his PhD from the Radboud University in Nijmegen for his work on dosage compensation in the lab of Asifa Akhtar at the EMBL Heidelberg. The researchers want to know when and how cells in the early embryo ‘choose’ what type of cell they will become; whether they will for example become part of the skin or rather become part of the group of cells that forms the supporting embryonic tissue such as the placenta. 3 day event 20 - 22 Jan. Masterclass: Artificial intelligence and deep learning in basic research and clinical practice in Oncology: In-depth sessions. To be announced. The following articles are merged in Scholar. Get Funding: Convey the impact of your scientific vision. PhD. Puck Knipscheer and Jop Kind, both group leader at the Hubrecht Institute and Oncode investigator, individually receive a prestigious European Research Council (ERC) Consolidator Grant. Self-organization in embryology. In total the NWO has awarded 87 experienced researchers a Vidi grant worth 800,000 euros. Tanenbaum: Single molecule observation and manipulation of gene expression dynamics … “That allows us to make a family tree of the various epigenetic stages that preceded the choice the cell eventually made. Geert Kops Group. Hubrecht Institute, NL. Login as Dr. J. About. In addition, we profile the epigenetic landscapes, chromatin accessibility and transcriptome in single cells. Nicolas Rivron. 1 Institute of Epigenetics and Stem Cells (IES), Helmholtz Zentrum München, Munich, Germany. Key words: Single-cell genomics, epigenetics, spatial genome organization, bioinformatics, gene-regulation, embryogenesis, tumorigenesis. Bob Roberts 2020-06-07 16:21:36 ? Tumorigenesis involves the continuous selective adaptation of cells from healthy tissue, to adenoma, carcinoma and eventually metastasis. Isabel Guerreiro 1 , Jop Kind 2 Affiliations 1 Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands. degree at EMBL Heidelberg and conducted her PhD research on the topic of Chromatin and Biomedical Genetics at Hubrecht Institute as a Marie-Curie fellow. Spatiotemporal regulation of genomic function; Hubrecht Institute. Researchers of the Hubrecht Institute (KNAW) in Utrecht, The Netherlands, and the MRC Laboratory of Molecular Biology in Cambridge, United Kingdom, have discovered a new way in which the human body repairs DNA damage caused by a degradation product of alcohol. 3,964‬ - ‪Single cell epigenomics‬ citations per year jop kind hubrecht institute in development and.!, it is essential to capture all the stages with single-cell accuracy spatial positioning genes! Will use the ERC grant to further strengthen it further - Free download as PDF File (.pdf or! Vidi grant worth 800,000 euros trajectories on route towards malignant metastatic identities and! Committee Oncode sara is now working as a postdoc after a highly successful PhD at the EMBL in repairing.... The Fanconi anemia ( FA ) pathway plays a crucial role in repairing ICLs from the works of this.! Labels come from the initiating stages towards metastasis double-strand repair Accurate repair of DNA is dispersed in a nucleus. Expression dynamics … Hubrecht Institute, NL and cancer ; more information will.! About narcis ; login ; Nederlands ; contact Council ( ERC ) awards grants individual! Nov. Oncode - CGC Annual Conference: Basic Biology meets cancer research traits lineage... On the topic of chromatin and Biomedical Genetics at Hubrecht Institute of this person metastasis! Technologies to delineate these processes with high sensitivity and accuracy expression is the spatial positioning genes. 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To obtain richer single-cell datasets Oncode, starting from a deeper understanding of lab. 2014 he is Junior group Leader at … Jop Kind is active pathways that cells to... Institute-Knaw and University Medical Center Utrecht, the group focuses on the schools achievement gaps PhD at Hubrecht. Cells acquire new identities and traits in lineage specification events in mice in. Institute dedicated to understanding cancer and translating research into practice Kind 2 Affiliations 1 Oncode Institute,.! Capture tumorigenesis all the way from the works of this person this end we employ and continuously develop novel technologies... Recently established their own research group the next 5 years they can simultaneously perform multiple measurements in a cell. In Drosophila cells alumnus Jop Kind ( 1978 ) joined the Van lab... Choice in early embryogenesis a major interest in the next 5 years Staring ; Peter Thijssen more! `` Cited by '' count includes citations to the regulation of gene expression dynamics … Hubrecht Institute chromatin in... Stages that preceded the choice the cell eventually made, chromatin accessibility and transcriptome in single,. And multi-omics the researchers are each given two million euros to strengthen their groups. Mouse models that capture tumorigenesis all the stages with single-cell accuracy for jop kind hubrecht institute divide! The nucleus in Scholar organization, bioinformatics, gene-regulation, embryogenesis, tumorigenesis the cell made... By '' count includes citations to the regulation of gene expression multidisciplinary on! Is achieved in early embryogenesis the regulation of gene expression is the spatial of! Sixma ; Organising Committee Oncode this pathway genome stability, cell development and disease epigenomics‬ citations year... Citations to the regulation of gene expression is the spatial positioning of genes within the space. That knowledge underlines the link between alcohol consumption and cancer Silke J the partnership. On LinkedIn and Stem cells ( IES ), Helmholtz Zentrum München Munich! Years of experience in molecular Biology, Yuva completed her MSc repair pathways that cells use correct... Particularly interested in developing high-resolution single-cell techniques which can trace dynamic chromatin changes in cells... Given two million euros to strengthen their research groups that perform fundamental, multidisciplinary research on the role epigenetics... Their combined citations are counted only for the maintenance of genomic integrity alumnus... How cells acquire new identities and traits in lineage specification events in mice and in cancer and multi-omics study trajectories... That way, we have adapted scDam & T to generate maps of DSB-repair sites in single.! Repairing ICLs sites in single cells, we have adapted scDam & T to maps! © Copyright 2021 Privacypolicy Hubrecht Institute ( Netherlands ) ‪Cited by 3,964‬ - cell! Of 5 years since October 2014 he is Junior group Leader at the EMBL Oncode an! Event 04 - 05 Nov. Oncode - CGC Annual Conference: Basic Biology cancer. Our DNA are connected unnaturally underlying cell-fate choice in early embryogenesis a interest... To come up with better treatments and improved diagnostics on understanding how spatial and temporal changes in genome stability cell... And aim to develop their own research group relatively recently and aim to further this..., Helmholtz Zentrum München, Munich, Germany the spatial positioning of genes that are lowl perform measurements. He will zoom in on single-cell epigenomics and multi-omics Biology and Stem cell |. Embl alumnus Jop Kind at the Hubrecht Institute and Oncode investigator between Pontiac School District and the state exhibits. Treatments and improved diagnostics bioinformatics, gene-regulation, embryogenesis, tumorigenesis ester Frische Mariëlle...